Movable lump labia majora4/26/2023 ![]() Microscopic appearance with Haematoxylin and Eosin and immunohistochemical staining has been shown in Figure 1. On the follow-up appointment at 4 months after the excision procedure, the patient was asymptomatic. These features were compatible with a GCT without features of malignancy. Immunohistochemistry showed that the tumor cells are S-100 positive. There are no mitoses and excision margins are free of tumour. However, there is no nuclear or cytological atypia. Microscopy revealed a poorly circumscribed, unencapsulated tumor composed of nests and strands of polygonal cells having abundant eosinophilic granular cytoplasm and small, central hyperchromatic nuclei. On slicing, the cut surface was pale tan. Macroscopically, the specimen measured 30 × 20 mm. An excision biopsy of the lesion was performed under regional anaesthesia. Preoperative ultrasound scan showed no increased vascularity around the lump. The lesion was nontender and on palpation there was no sign of discharge or bleeding. It was fixed to the overlying skin which had a normal appearance. The physical examination revealed a hard, mobile, nodular, subdermal, mass measuring 30 × 20 mm over the mons pubis and it was about 2 cm superior to the clitoris and 1 cm lateral to the midline. Her past history and family history revealed nothing significant. She denied any history of previous vulvar lesion or any other systemic symptoms. She has no history of pain, discharge, or any bleeding from the area. Case ReportĪ 27-year-old nulliparous woman presented with an increasing vulval lump for 2-year duration without any significant associated symptoms. This location of mons pubis is hardly reported in the literature and only two cases were found in English literature. This case describes a benign GCT over the mons pubis of vulva in a 27-year-old woman. The aggressive malignant form of GCT exhibits a poor response to radiotherapy and chemotherapy. Although most vulval GCT are benign, about 1 to 2% of the cases are malignant and may be associated with regional or distant metastases. Commonest reported site of GCT in the female genital tract is on the labium majus. Macroscopically, GCT are small, firm, solitary whitish nodules with poor encapsulation. Most cases are sporadic and are located in the subcutaneous layer. Granular cell tumors (GCT) are uncommon slow-growing soft tissue tumors, considered to be derived from peripheral nerves, particularly Schwann cells. Here, we present a benign granular cell tumor over the mons pubis of vulva in a 27-year-old woman. Complete surgical excision is the preferred treatment of choice to prevent recurrence. They occur throughout the body vulval involvement is uncommon and labium majus is the commonest site in vulva. DOI: 10.3892/ cell tumors are uncommon, usually benign, soft tissue neoplasms of neural origin. Local recurrent vaginal aggressive angiomyxoma misdiagnosed as cellular angiomyofibroblastoma: A case report. health-topics/vaginal-cysts-polyps-and-warts diseases-conditions/vaginal-cancer/symptoms-causes/syc-20352447 ![]() diseases-conditions/bartholin-cyst/symptoms-causes/syc-20369976 Aggressive angiomyxoma of the vagina: A case report. ![]() You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations.
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